Alpha Control was the organization in charge of the Jupiter Mission. it is seen in The Reluctant Stowaway, The Derelict, and Time Merchant, as well as being mentioned or contacted in several other episodes. They also launched a series of Fuel Barges to the Siribidus Galaxy as refueling stations for the Intergalactic Probe 22 in 1996. The Jupiter 2 briefly made radio contact with Alpha Control when they were near Earth. Unfortunately, the ship did not have enough fuel to reach home ("Wild Adventure").
In the Lost in Space reboot series, Alpha Control appears in the episode Contingencies on Contingencies, voiced by June Lockhart.